What is Process Understanding (and why should I care about it)?
Process Metrics - The Key To Process Understanding
Process metrics (PMs) are physical variables that describe some aspect of the internal environment of a unit operation. For instance, in an agitated vessel bioreactor, the shear rate near the impeller is a PM with specific reference to oxygen transfer.
Generally speaking, maintaining these PMs at the same (or nearly same) values across scales is a necessary condition for maintaining product quality and process performance during scale-up or scale-down.
Asset Digitalization For Succesful Process Transfer
Asset digitalization is an important step in determining the process performance capability of a given unit operations equipment. It enables the systematic utilization of process understanding to drive successful fundamentals-based development / transfer.